DNA methylation can be considered a component of epigenetic memory with a critical role during embryo development, and which undergoes dramatic reprogramming after fertilization. Though it has been a focus of research for many years, the reprogramming mechanism is still not fully understood. Recent results suggest that absence of maintenance at DNA replication is a major factor, and that there is an unexpected role for TET3-mediated oxidation of 5mC to 5hmC in guarding against de novo methylation. Base-resolution and genome-wide profiling (...) methods are enabling more comprehensive assessments of the extent to which ART might impair DNA methylation reprogramming, and which sequence elements are most vulnerable. Indeed, as we also review here, studies showing the effect of culture media, ovarian stimulation or embryo transfer on the methylation pattern of embryos emphasize the need to face ART-associated defects and search for strategies to mitigate adverse effects on the health of ART-derived children. DNA methylation, critical for embryo development, suffers significant changes after fertilization, including demethylation, remethylation and TET3-mediated oxidation of 5 mC to 5 hmC. In addition to infertility and environmental insults, ART could impact DNA methylation and ART related consequences in the offspring have been reported. (shrink)

Sobre el libro: Isaiah Berlin ha sido, además de un original e intuitivo historiador de las ideas y autor de numerosos conceptos teórico-políticos, un reconocido teorizador de la libertad y defensor acérrimo del pluralismo. Rasgos que lo han convertido en un innegable referente intelectual en nuestra época. Sobre el editor: El Editor de la presente obra, Pablo Badillo O'Farrell, con motivo del centenario del nacimiento de Berlin, ha reunido un número de contribuciones de estudiosos italianos y españoles que (...) ofrecen, desde muy diferentes perspectivas, un amplio abanico de miradas diversas sobre la obra y el pensamiento del autor, que van desde el análisis y confrontación del pluralismo valorativo y la ética de la libertad, al de la interculturalidad o la identidad personal y el nacionalismo, pasando por la confrontación de historicismo, historia de las ideas y contra-corriente. (shrink)

Este libro incide, tanto en los artículos de Collingwood, inéditos hasta ahora en castellano, como en un conjunto de estudios que buscan desentrañar su pensamiento, aun vigente y anticipador de muchos problemas y cuestiones de la actualidad.

Este libro incide, tanto en los artículos de Collingwood, inéditos hasta ahora en castellano, como en un conjunto de estudios que buscan desentrañar su pensamiento, aun vigente y anticipador de muchos problemas y cuestiones de la actualidad.

Este estudio bibliográfico y crítico es un apéndice correspondiente al ensayo de P. Badillo titulado "Scienza Nuova y The New Science of Politics: Proyección del pensamiento viquiano en la obra de Eric Voegelin" , donde ahora el mismo autor extiende sus reflexiones a propósito de la reciente edición del libro de Voegelin titulado La ‘Scienza Nuova’ nella storia del pensiero politico. This bibliographical and critical study is an appendix to P. Badillo’s paper "Scienza Nuova y The New Science (...) of Politics: Proyección del pensamiento viquiano en la obra de Eric Voegelin" in which the same author expands his reflections on the event of the recent publication of Voegelin’s book La ‘Scienza Nuova’ nella storia del pensiero politico. (shrink)

The practice of physical activity (PA) contributes to the prevention of chronic diseases such as obesity, metabolic syndrome or cardiovascular diseases, being also directly related to the individual’s physical fitness. Therefore, it is necessary to measure and monitoring the levels of PA in childhood and adolescence, since it may be useful to describe their current health status and the association with physical fitness, as well as to reveal putative consequences in the future. Within the educational field, it has been shown (...) that physical education (PE) classes are a favorable context for the creation of healthy physical-sports habits and self-determined motivation could be a key for explaining the level of PA practice. For this reason, the purpose of this research was to study the mediating role of integrated regulation (IR) on the relationship between PA and physical fitness in children and adolescents. A total of 325 students between 11 and 14 years old participated in the study. The level of PA was estimated through the specific Physical Activity Questionnaire for Children (PAQ-C), while motivation and IR were measured by using the Perceived Locus of Causality scale (PLOC-2). In addition, physical fitness was measured through the Eurofit fitness battery of tests, composed of three body composition measures and seven tests of different physical capacities. The physical fitness score showed no differences when genders were compared. After regression analysis, the resulti... (shrink)

Este volumen recoge las lecciones del X Curso de Cultura hispanojudía y sefardí de la Universidad de Castilla-La Mancha, organizado por la Asociación de Amigos del Museo Sefardí (Toledo, Septiembre 2000) y consagrado al Pensamiento y Mística hispanojudía y sefardí. Las quince conferencias aquí reunidas ofrecen una perspectiva amplia, representativa y completa de los momentos, autores y temas más significativos tratados por pensadores y místicos sefardíes desde la Edad Media hasta nuestros días. Se aprecia una continuidad en los problemas y (...) una búsqueda constante de nuevas soluciones, adaptadas a las circunstancias de cada época. Es la primera vez que aparece en lengua castellana una visión global de esta rica faceta de la cultura hispanohebrea, que permite al lector acercarse a la evolución del pensamiento de los judíos originarios de Sefarad antes y después de 1492, tanto en su faceta filosófica con en su faceta mística (cábala). (shrink)

Este estudio buscó describir e interpretar las teorías subjetivas sobre la identidad profesional docente que se construyen y difunden noticiosamente durante la educación de emergencia por la pandemia de COVID 19. Se utilizó un estudio de análisis documental, metodología cualitativa y un diseño de estudio de casos. El muestreo intencionado y por conveniencia corresponde a 40 noticias de prensa escrita en español, sobre el profesor(a) en pandemia y publicadas en diferentes medios que fueron recolectadas a través de Google Noticias desde (...) el 11 de marzo de 2020 y hasta el 01 de noviembre de 2020. A partir de una codificación temática, los resultados evidenciaron teorías subjetivas asociadas a las exigentes características, roles, funciones y valores con los que se identifica al profesorado durante la pandemia. El análisis mostró los distintos sentidos del ejercicio profesional y las competencias asociadas a su desempeño en la prensa. En la discusión, se utilizaron estudios relativos a la práctica docente para interpretar estos resultados. (shrink)

Boceto de la receptio viquiana en R. G. Collingwood Pablo Badillo O’Farrell Este estudio aborda y esboza, en un tratamiento inédito en español, la recepción de Vico en el filósofo e historiador inglés R.G. Collingwood.PALABRAS CLAVE: Vico, Collingwood, historia, filosofía política, autobiografía, Croce.This study deals for the first time in Spanish with Vico’s reception by the English philosopher and historian R.G. Collingwood.KEYWORDS: Vico, Collingwood, history, political philosophy, autobiography, Croce.

Estudio Bibliográfico de / A Bibliographical Study of: New Vico Studies , 19 , Special Issue on Vico and Roman Law. The Institute for Vico Studies, Atlanta, Donald Phillip Verene , pp. 199.

No obstante las escasas referencias explícitas a Vico en la obra de Voegelin, se busca mostrar la incidencia del pensamiento del napolitano en la obra del autor de The New Science of Politics, en cuanto ambos luchan contra tendencias de desdivinización; el primero contra el racionalismo cartesiano y el segundo contra el positivismo.

Estudio bibliográfico de / A bibliographical study of: Gennaro Carillo, Vico. Origine e genealogia dell'ordine , Editoriale Scientifica, Napoli, 2000, 507 pp.

Este volumen articula una treintena de contribuciones de entre las presentadas a las XIV Jornadas Internacionales de Hispanismo Filosófico, organizadas por la Asociación de Hispanismo Filosófico y celebradas en la Universidad de Sevilla del 3-5 de abril de 2019, dedicadas a los relatos de cosmopolitismo en la filosofía hispánica. Todos los capítulos aquí presentados vienen agavillados con la fuerte cinta del pluralismo, como fiel reflejo de que no se puede hablar de relato del cosmopolitismo en el pensamiento español e iberoamericano (...) en singular sino en plural, precisamente, porque son muchos y diversos los relatos. En definitiva, el lector se encuentra ante una gran obra en la que los relatos de cosmopolitismo nos conducen a un lugar común, gracias a que los diferentes caminos escogidos se terminan felizmente encontrando en ese espacio vital del hispanismo filosófico en el que, junto al pensamiento reflexivo y la hermenéutica, se encuentra la indagación histórica. (shrink)

Burnout is characterized by emotional exhaustion and caused by exposure to excessive and prolonged stress related to job conditions. Moreover, burnout is highly prevalent among health care professionals. The aim of this study is, first, to examine the mediating role of social support over the effect of burnout in health care professionals and, second, to explore potential gender differences. A convenience sample of 1,035 health professionals from Ecuador, including 608 physicians and 427 nurses, was surveyed using the Maslach Burnout Inventory, (...) Social Support Survey, and General Health Questionnaire as measures of burnout, social support, and general health, respectively. Social support was found to mediate the negative effects of burnout on health regardless of gender. Differences across the three dimensions of burnout and health are further discussed, along with their implications for designing effective burnout interventions for health care professionals in Ecuador. (shrink)

Business Ethics: A European Review, EarlyView.

Most research studying the corporate social performance –corporate financial performance link has utilized developed country samples. Also, this literature has generally focused on a wide variety of industries, ignoring the fact that certain sectors – such as controversial industries – have graver social and environmental issues. Hence, a gap exists in this tradition when it comes to emerging markets and controversial industries. This paper attempts to fill this void by providing preliminary evidence and insight on the matter. Based on an (...) exploration in six Latin American countries and five controversial industries, we find a negative bidirectional association between CSP and CFP. These results tend to contradict the mainstream conclusion of a positive bidirectional link, suggesting that institutional and market-level forces play a major role in shaping this relationship. (shrink)

El artículo analiza la influencia del pensamiento de Francisco Suárez sobre el de Giambattista Vico, y se ocupa básicamente de analizar los conceptos de derecho natural y de gentes en el primero, que en el segundo se acaba convirtiendo en Derecho natural de gentes. La concepción de Suárez sobre el derecho natural se sustenta en afirmar la no inmutabilidad plena de éste y se combina con el derecho de gentes, en el que se comprenden las costumbres de los distintos pueblos. (...) La idea viquiana del derecho natural de gentes abre las puertas al historicismo y al culturalismo como la base en la que sustenta dicho derecho, lo que supone una visión claramente humanista y pluralista del orden normativo, frente al abstractismo racionalista ilustrado. (shrink)

No obstante las escasas referencias explícitas a Vico en la obra de Voegelin, se busca mostrar la incidencia del pensamiento del napolitano en la obra del autor de The New Science of Politics, en cuanto ambos luchan contra tendencias de desdivinización; el primero contra el racionalismo cartesiano y el segundo contra el positivismo.

Conservation scholarship and policies are concerned with the viability of idealized ecological communities constructed using human metrics. We argue that the discipline of conservation assumes an epistemology and ethics of human sovereignty/dominion over animals that leads to violent actions against animals. We substantiate our argument by deconstructing a case study. In the context of recent bushfires in Australia, we examine recent legislation passed by the parliament of New South Wales, policy documents, and academic articles by conservationists that support breaking communities (...) of horses and/or killing 4,000 horses in Kosciuszko National Park, NSW. Theoretically framing our deconstruction against human sovereignty over animals and anthropocentrism, we affirm an intersectional, ecofeminist approach that values animals as relational and vulnerable agents. We uncover first the epistemic violence of categorizing horses as “pests,” and the anthropocentric nature of recently passed legislation in NSW. We analyze next the deficient ethics of NSW's government, and the argument that killing animals is justifiable when they suffer from starvation and dehydration. We close with a realistic proposal that does not involve breaking horses’ communities and/or killing horses, and a plea to the government of NSW and conservationists not to harm any horses in KNP. (shrink)

Even though the link between perceived corporate social responsibility fit and corporate reputation has received much attention from scholars, this tradition has ignored that the underpinnings of this association vary depending on the particular characteristics of each industry under study. To delve into this matter, we investigate in the increasingly relevant context of controversial industries how PCSR-fit could enhance corporate reputation and which are the mediating mechanisms of this association. Our academic contribution is twofold. First, we find that controversial sectors (...) indeed can increase corporate reputation through CSR activities. However, we find that to achieve this goal, the nature of PCSR-fit should be different than what extant literature indicates, because companies in these settings should directly focus on avoiding or reducing their inherent controversial harm or impact. Second, we evidence that “CSR initiatives' legitimacy” and “situational skepticism” mediate the PCSR-fit and corporate reputation relationship in CIs. Therefore, we further unravel the underpinnings of this association to advance what we know on the matter and aid practitioners in this particular context. (shrink)

Traditionally, research focused on determining the causes of employee pay satisfaction has investigated the influence of job-related inputs, both extrinsic and intrinsic to the job itself. Together with these inputs, pay-related fairness issues have played an important role in explaining the phenomenon. However, few studies consider the factors linked to fairness issues, such as ethical leadership. Because ethical leadership necessarily entails the concept of fairness, it seemingly should have a positive effect. Furthermore, because the presence of supervisor ethical leadership (SEL) (...) offers strong chances for employees to achieve moral accomplishments and excel in the practice of their jobs, SEL should enhance the effects of intrinsic job inputs. Whereas high job motivating potential (JMP) makes it easier for employees be self-actualized, moral fulfillment is necessary for them to obtain authentic self-actualization at work and minimize the impact of pay deficiencies. Along with SEL, JMP should be shaped to increase positive experiences of job meaningfulness, responsibility for job outcomes, and knowledge of results at work, which can lead to enjoyment in doing the job in itself, not just for compensation-related motives. Hierarchical regression analysis with a sample of 151 employees in a diverse set of Spanish organizations supports the direct effects of JMP and SEL and shows that higher levels of SEL increase the positive effects of JMP on pay satisfaction. The practical implications of these findings and further research directions conclude this article. (shrink)

Background The expressions of a “wish to hasten death” or “wish to die” raise ethical concerns and challenges. These expressions are related to ethical principles intertwined within the field of medical ethics, particularly in end-of-life care. Although some reviews were conducted about this topic, none of them provides an in-depth analysis of the meanings behind the “wish to hasten death/die” based specifically on the ethical principles of autonomy, dignity, and vulnerability. The aim of this review is to understand if and (...) how the meanings behind the “wish to hasten death/die” relate to and are interpreted in light of ethical principles in palliative care. Methods We conducted a meta-ethnographic review according to the PRISMA guidelines and aligned with Noblit and Hare’s framework. Searches were performed in three databases, Web of Science, PubMed, CINAHL, with no time restrictions. Original qualitative studies exploring the meanings given by patients, family caregivers and healthcare professionals in any context of palliative and end-of-life care were included. A narrative synthesis was undertaken. PROSPERO registration CRD42023360330. Results Out of 893 retrieved articles, 26 were included in the analysis, accounting for the meanings of a total of 2,398 participants. Several factors and meanings associated with the “wish to hasten death” and/or “wish to die” were identified and are mainly of a psychosocial and spiritual nature. The ethical principles of autonomy and dignity were the ones mostly associated with the “wish to hasten death”. Ethical principles were essentially inferred from the content of included articles, although not explicitly stated as bioethical principles. Conclusions This meta-ethnographic review shows a reduced number of qualitative studies on the “wish to hasten death” and/or “wish to die” explicitly stating ethical principles. This suggests a lack of bioethical reflection and reasoning in the empirical end-of-life literature and a lack of embedded ethics in clinical practice. There is a need for healthcare professionals to address these topics compassionately and ethically, taking into account the unique perspectives of patients and family members. More qualitative studies on the meanings behind a wish to hasten death, their ethical contours, ethical reasoning, and implications for clinical practice are needed. (shrink)

BackgroundThe globalization of medical science carries for doctors worldwide a correlative duty to deepen their understanding of patients' cultural contexts and religious backgrounds, in order to satisfy each as a unique individual. To become better informed, practitioners may turn to MedLine, but it is unclear whether the information found there is an accurate representation of culture and religion. To test MedLine's representation of this field, we chose the topic of death and dying in the three major monotheistic religions.MethodsWe searched MedLine (...) using PubMed in order to retrieve and thematically analyze full-length scholarly journal papers or case reports dealing with religious traditions and end-of-life care. Our search consisted of a string of words that included the most common denominations of the three religions, the standard heading terms used by the National Reference Center for Bioethics Literature (NRCBL), and the Medical Subject Headings (MeSH) used by the National Library of Medicine. Eligible articles were limited to English-language papers with an abstract.ResultsWe found that while a bibliographic search in MedLine on this topic produced instant results and some valuable literature, the aggregate reflected a selection bias. American writers were over-represented given the global prevalence of these religious traditions. Denominationally affiliated authors predominated in representing the Christian traditions. The Islamic tradition was under-represented.ConclusionMedLine's capability to identify the most current, reliable and accurate information about purely scientific topics should not be assumed to be the same case when considering the interface of religion, culture and end-of-life care. (shrink)

Informed consent is a perennial topic in bioethics. It has given the field a place in clinical practice and the law and is often the starting point for introductory instruction in medical ethics. One would think that nearly everything has been said and done on this well-worn topic.

Variation in the durations of exclusive breastfeeding (exBF) and any breastfeeding (anyBF) is associated with socioecological factors. This plasticity in breastfeeding behavior appears adaptive, but the mechanisms involved are unclear. With this concept in mind, we investigated whether durations of exBF and anyBF in a rural Maya population covary with markers of a form of socioecological change—market integration—and whether individual factors (individual learning, physiological plasticity) and/or learning from others in the community (social learning, norm adherence) mediate these changes. Using data (...) from 419 mother-child pairs from two Guatemalan Maya villages, we fit a bivariate linear mixed model. The model compared exBF and anyBF among children from households of varying degrees of market integration whose mothers follow what we inferred to be local infant-feeding norms. It controlled for other factors expected to affect breastfeeding durations. We found evidence that exBF is associated with whether mothers follow their population’s infant feeding norms, but no evidence that exBF is associated with the household’s level of market integration. Conversely, anyBF is significantly associated with the household’s market integration, but not with the villages’ inferred norms. Because deviations from exBF norms are likely to result in infant mortality and reduced fitness, we hypothesize that the incentive to conform is relatively strong. Relatively greater individual plasticity in anyBF allows mother-child pairs to tailor it to socioecological conditions. Deviations from anyBF norms may be tolerated because they may provide later-life health/fitness payoffs, while posing few risks to infant survival. (shrink)